I have put together a bunch of links and research here for our subscribers to use in seeking the truth about 293 Human Cells and your ethical choice!
Oklahoma State Senator Ralph Shortey introduced a bill that would ban “the manufacture or sale of food or products which use aborted human fetuses.”
PepsiCo for working with a company called Senomyx that “has been accused of using proteins derived from human embryonic kidney cells in its research.” Address San Diego, CA 92121-3051
United States Phone+1-858-6468300 Fax 858-4040752 Web www.senomyx.com
HEK 293 cells But some food companies are using cell lines that were originally derived from human fetuses in order to develop new food products. … The cells, called HEK 293 cells (that stands for human embryonic kidney) were taken from an aborted fetus in the 1970s in the Netherlands. Human cloned DNA in your foods people no joke
The cells, called HEK 293 cells (that stands for human embryonic kidney) were taken from an aborted fetus in the 1970s in the Netherlands.
The Original Unnamed aborted babies cell culture cell line isn’t leading to new abortions but it sure is human DNA.
(Here’s: the original paper on the creation of the 293 Human HEK cells. )
Origins of the HEK293 Cell Line
HEK293 is a cell line derived from human embryonic kidney cells grown in tissue culture. They are also known, more informally, as HEK cells. This particular line was initiated by the transformation and culturing of normal HEK cells with sheared adenovirus 5 DNA. The transformation resulted in the incorporation of approximately 4.5 kilobases from the viral genome into human chromosome 19 of the HEK cells. The line was cultured by scientist Alex Van der Eb in the early 1970s at his lab at the University of Leiden, Holland. The transformation was executed by Frank Graham, another scientist Van der Eb’s lab who invented the calcium phosphate method for transfecting cells. The source of the cells was a healthy aborted fetus of unknown parenthood. The name HEK293 is thusly named because it was Frank Graham’s 293rd experiment.
The type of kidney cell that the HEK293 cell line came arose from is unknown and it is difficult to conclusively characterize the cells post-transformation since adenovirus 5 could have significantly disrupted cell morphology and expression. Also, embryonic kidneys are a heterogeneous mix of almost all the types of cells present in the body. In fact, it has been speculated by independent researchers, including Van der Eb himself, that the cells may be neuronal in origin. Although theoretically possible, most cells derived from an embryonic kidney would be endothelial, epithelial or fibroblast cells. Neuronal origin is suspected due to the presence of mRNA and gene products typically found in neurons.
Today, HEK293 cells are frequently used in cell biology and biotechnology, second only to HeLa, the first human cell line. Around establishment of HeLa in 1951, scientists were reluctant to accept and use human cell lines out of concern for an oncogenic agent in them. This concern, along with the known ability of animal cell lines to grow rapidly and yield a high amount of proteins, gave scientists reason to favor animal cell lines over human cell lines when producing recombinant proteins. However, advances in technology since then have allowed for an increase in human cell line use. One advantage of human cell lines is that they are able to produce proteins most similar to those that humans naturally synthesize. Now there are approved recombinant biotherapeutic products produced from HEK293 and other human cell lines.
HEK293 and its derivatives are used in a wide range of experiments, including signal transduction and protein interaction studies, rapid small-scale protein production, and biopharmaceutical production. HEK293 cells easily grow in suspension serum-free culture, reproduce rapidly, and produce high levels of protein, which explains why they have been widely used to produce research-grade proteins for a number of years.
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Download HEK293 transfection protocol: [PDF]
- Download HEK293 CRISPR/Cas9 transfection protocol: [PDF]
- Download PowerPoint presentation for HEK293 cells transfection kit: [PPT]
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Developed and manufactured by Altogen Biosystems
Andy-Kaufman-esque stunt articles on Gawker
(See a list of products Children of God For Life say are unethical.)
Biotech’s Fear Factor – Forbes
“We’re helping companies clean up their labels,” said Senomyx’s chief executive, Kent Snyder.
Senomyx, based in San Diego, uses many of the same research techniques that biotechnology companies apply in devising new drugs. Executives say that a taste receptor or family of receptors on the tongue or in the mouth are responsible for recognizing a taste. Using the human genome sequence, the company says, it has identified hundreds of those taste receptors. Its chemical compounds activate the receptors in a way that accentuates the taste of sugar or salt. It is still experimenting to determine the most potent compounds, its chief scientist, Mark Zoller, said.
But Senomyx maintains that its new products are safe because they will be used in tiny quantities.
Kraft, Nestlé, Coca-Cola and Campbell Soup have contracted with Senomyx for exclusive rights to use the ingredients in certain types of food and beverages, although the companies declined to identify those categories.
Elise Wang, an analyst at Smith Barney, said that Kraft was planning to use Senomyx’s sweet flavoring to reduce the sugar in powdered beverages like Kool-Aid by one-third. Campbell Soup, she said, is looking at cutting sodium levels by a third with the salt flavoring.
Cost Effective
Senomyx is an American biotechnology company working toward developing additives to amplify certain flavors and smells in foods. The company claims to have essentially “reverse engineered” the receptors in humans that react for taste and aroma, and that they are capitalizing on these discoveries to produce chemicals that will make food taste better. On 17 Sept 2018, Firmenich completed the acquisition of Senomyx. [1]
Senomyx develops patented flavor enhancers by using “proprietary taste receptor-based assay systems”, which have been previously expressed in human cell culture, in HEK293 cells.[2]
HEK293 cells are a cell line widely used in biological and medical research, immortalised through a genetic modification removed from the original human embryonic kidney cells taken from a healthy, electively aborted human fetus in the early 1970s.[3] The receptors in the assay are used to identify flavours; they are not used as flavours themselves. No human taste receptors are used as ingredients in any flavourings. Using information from the human genome sequence, Senomyx has identified hundreds of taste receptors and currently owns 113 patents on their discoveries. Senomyx collaborates with seven of the world’s largest food companies to further their research and to fund development of their technology.
Cell Applications, Inc
5820 Oberlin Drive, Suite 101
San Diego, CA 92121
Open M-F, 8am-5pm PST
SEARCH RESULTS
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CYTOFECT™: HIGH EFFICIENCY
TF780K RH TOP Cytofect™ Cell Line Transfection Kit- Cat. No. TF104K 293 … Cervical Epithelial Adenocarcinoma (HeLa) Human Embryonic Kidney (293 …
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CYTOFECT™: LOW TOXICITY
Health, Viability and Morphology 293 HBEpC HDF HEK HUVEC RBMVEC … Epithelial Adenocarcinoma (HeLa) Human Embryonic Kidney (293 …
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TRANSFECTION FAQ
HEK 293 CHO HeLa MCF-7 Cytofect™-Omni Transfection Kit All primary cells …
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WHY PRIMARY CELLS?
media like DMEM and RPMI, and immortalized cell lines (HeLa, HEK 293 …
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CYTOFECT™ CELL LINE TRANSFECTION KIT
Instructions TF104K Instructions TF104KS …
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GROWTH FACTORS & CYTOKINES
PURE, BIOACTIVE, RECOMBINANT PROTEINS
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ANTIBODIES
DETECT PROTEINS, GROWTH FACTORS
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CELL COUNTING
CYTO-X, MTT & DIL-AC-LDL KITS
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CELL RNA
PURIFIED TOTAL RNA READY-FOR-USE
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TISSUE RNA
STABILITY-TESTED TOTAL RNA
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ELISA
READY-TO-USE PROTEIN DETECTION
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GENE EXPRESSION
BETA GAL & X-GAL ASSAY KITS
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TRANSFECTION
HIGH EFFICIENCY & VIABILITY
SEARCH
SEARCH RESULTS 293 product
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ANTI-AGER: POLYCLONAL ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR, RAGE, ANTIBODY
Product Sheet CA1789 …
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ANTI-RSK2: MOUSE RSK2 ANTIBODY PRODUCT
Product Sheet CP10433 …
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PRODUCT INFORMATION
in these cell types. Both the BPE and BBE products are aqueous extracts. The BPE …
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NEW PRODUCTS
Cardiomyocyte Media Human iPSC iPSC-Der Cardiomyocytes Cellular Asthma Models Small Airway EpC Neural Stem Cells Trabecular Cells Cellular COPD Models iPSC-Derived HNSC Perineurial Fibroblasts Renal Glomular Cells iPSC-Derived HNSC Rat …
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WHY PRIMARY CELLS?
types, complimented by optimized products to serve life science R&D … media like DMEM and RPMI, and immortalized cell lines (HeLa, HEK 293 … testing and certification, so the procedures and product remains consistent. …
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CYTOFECT™: HIGH EFFICIENCY
TF780K RH TOP Cytofect™ Cell Line Transfection Kit- Cat. No. TF104K 293 … Cervical Epithelial Adenocarcinoma (HeLa) Human Embryonic Kidney (293 …
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CYTOFECT™: LOW TOXICITY
Health, Viability and Morphology 293 HBEpC HDF HEK HUVEC RBMVEC … Epithelial Adenocarcinoma (HeLa) Human Embryonic Kidney (293 …
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TRANSFECTION FAQ
HEK 293 CHO HeLa MCF-7 Cytofect™-Omni Transfection Kit All primary cells …
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TERMS
I. TERMS OF USE Cell Applications, Inc. (“CAI”) will sell products … of the CAI’s products (such as to collect a debt, resolve a dispute … by delays in receiving orders. VI. PRODUCT USE AND RECOMMENDATIONS All …
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GDNF: MOUSE GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
Product Sheet 2037 Product Sheet 2037AF …
References
- ^ Schultz, SA Editor Clark (17 September 2018). “Firmenich to acquire Senomyx”. Seeking Alpha. Retrieved 18 September 2018.
- ^ Li, X; Staszewski, L; Xu, H; Durick, K; Zoller, M; Adler, E (April 2002). “Human receptors for sweet and umami taste”. Proc. Natl. Acad. Sci. U.S.A. 99: 4692–6. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
- ^ Vaccines and Related Biological Products Advisory Committee Meeting, p.81 , Center for Biologics Evaluation and Research, May 16, 2001
- ^ Jack Samuels, Wise Traditions in Food, Farming and the Healing Arts, the quarterly magazine of the Weston A. Price Foundation, Spring 2008.
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By Year Late-Breaking Yamakami et al, Mar 2019 (HEK)
Cardenas et al, Mar 2018 (HAOSMC & Media)
Izzicupo et al, Dec 2017 (HUVEC)
Wang et al, May 2017 (HFDPC & Media)
Fercana et al, Apr 2017 (Human EC Gr Media)
Szymiczek et al, Mar 6 (HUVEC)
Tarade et al, Mar 2 (HOb & Media)
Gardner et al, Mar 1, 2017 (Human EC & Media)
2019
Human Smooth Muscle Cell Growth Medium
Srihirun, S., Park, J. W., Teng, R., Sawaengdee, W., Piknova, B., & Schechter, A. N. (2019). Nitrate uptake and metabolism in human skeletal muscle cell cultures. Nitric Oxide.
Human Aortic Smooth Muscle Cells: HAOSMC
Lu, Y., Sun, X., Peng, L., Jiang, W., Li, W., Yuan, H., & Cai, J. (2019). Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V-MEK/ERK mediated mechanism. International Journal of Cardiology.
Human Dermal Fibroblasts: HDF
Chaudhuri, R. K., Meyer, T., Premi, S., & Brash, D. Acetyl Zingerone (2019): An efficacious multifunctional ingredient for continued protection against on‐going DNA damage in melanocytes after sun exposure ends. International Journal of Cosmetic Science.
Human Coronary Artery Endothelial Cells: HCAEC
Gamon, L. F., Dieterich, S., Ignasiak, M. T., Schrameyer, V., & Davies, M. J. (2019). Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase. Redox Biology, 101331.
Rat Dermal Fibroblasts: RDF
Palungwachira, P., Tancharoen, S., Phruksaniyom, C., Klungsaeng, S., Srichan, R., Kikuchi, K., & Nararatwanchai, T. (2019). Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts. Oxidative Medicine and Cellular Longevity, 2019.
Human Dermal Fibroblasts: HDF
Wang, X., Hong, H., & Wu, J. (2019). Hen collagen hydrolysate alleviates UVA-induced damage in human dermal fibroblasts. Journal of Functional Foods, 63, 103574.
Human Epidermal Keratinocytes: HEK
Chaudhuri, R. K., Meyer, T., Premi, S., & Brash, D. Acetyl Zingerone (2019): An efficacious multifunctional ingredient for continued protection against on‐going DNA damage in melanocytes after sun exposure ends. International Journal of Cosmetic Science.
Human Umbilical Vein Endothelial Cells: HUVEC
Matsunuma, S., Handa, S., Kamei, D., Yamamoto, H., Okuyama, K., & Kato, Y. (2019). Oxaliplatin induces prostaglandin E2 release in vascular endothelial cells. Cancer Chemotherapy and Pharmacology, 1-6.
Human Pulmonary Artery Endothelial Cells: HPAEC
Blais-Lecours, P., Laouafa, S., Arias-Reyes, C., Santos, W. L., Joseph, V., Burgess, J. K., … & Marsolais, D. (2019). Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. American Journal of Respiratory Cell and Molecular Biology,
Bovine Aortic Endothelial Cells: BAOEC
Ogata, F., Nakamura, T., Nakajima, M., Toda, M., Otani, M., & Kawasaki, N. (2019). PO43− adsorption in a complex solution by nickel–cobalt hydroxide, and its cytotoxicity on bovine aortic endothelial cells. Journal of Environmental Chemical Engineering.
MesoEndo Cell Growth Medium
Detsika, M. G., Myrtsi, E. D., Koulocheri, S. D., Haroutounian, S. A., Lianos, E. A., & Roussos, C. (2019). Induction of decay accelerating factor and membrane cofactor protein by resveratrol attenuates complement deposition in human coronary artery endothelial cells. Biochemistry and Biophysics Reports, 19, 100652.
Rat Pulmonary Artery Smooth Muscle Cells: RPASMC
Suzuki, Y. J., Marcocci, L., Shimomura, T., Tatenaka, Y., Ohuchi, Y., & Brelidze, T. I. (2019). Protein Redox State Monitoring Studies of Thiol Reactivity. Antioxidants, 8 (5), 143.
Human Coronary Artery Endothelial Cells: HCAEC
Lorentzen, L. G., Chuang, C. Y., Rogowska-Wrzesinska, A., & Davies, M. J. (2019). Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications. Redox Biology, 101226.
Human Liver, Spleen, Kidney and Testes RNA
Swystun, L. L., Ogiwara, K., Lai, J. D., Ojala, J. R., Rawley, O., Lassalle, F., … & Tryggvason, K. (2019). The scavenger receptor SCARA 5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen. Journal of Thrombosis and Haemostasis.
Human Umbilical Vein Endothelial Cells: HUVEC
Brines, M. and Cerami, A., (2019). TISSUE PROTECTIVE PEPTIDES FOR PREVENTING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH TISSUE DAMAGE. U.S. Patent Application 16/096,247.
Human Dermal Fibroblasts: HDF
Yang, H., Sun, J., Chen, H., Wang, F., Li, Y., Wang, H., & Qu, T. (2019). Mesenchymal stem cells from bone marrow attenuated the chronic morphine-induced cAMP accumulation in vitro. Neuroscience letters, 698, 76-80.
Human EpiVita Serum-Free Growth Medium
Lin, E. S., Chang, W. A., Chen, Y. Y., Wu, L. Y., Chen, Y. J., & Kuo, P. L. (2019). Deduction of Novel Genes Potentially Involved in Keratinocytes of Type 2 Diabetes Using Next-Generation Sequencing and Bioinformatics Approaches. Journal of clinical medicine, 8(1), 73.
Human Carotid Artery Smooth Muscle Cells: HCtASMC
Aldi, S., Eriksson, L., Kronqvist, M., Lengquist, M., Löfling, M., Folkersen, L…& Österholm, C. (2019). Dual roles of heparanase in human carotid plaque calcification. Atherosclerosis.
Human Umbilical Vein Endothelial Cells: HUVEC
Swaminathan, S., Hamid, Q., Sun, W., & Clyne, A. M. (2019). Bioprinting of 3D breast epithelial spheroids for human cancer models. Biofabrication.
MesoEndo Cell Growth Medium
Pott, G. B., Tsurudome, M., Proctor, L. L., & Goalstone, M. L. (2019). CIGARETTE SMOKE EXTRACT, KALLIKREIN-6 AND APROTININ REGULATE PRODUCTION OF SOLUBLE VCAM-1 AND ICAM-1 IN HUMAN CAROTID ENDOTHELIAL CELLS.
Human Epidermal Keratinocytes: HEK
Yamakami, Y., Morino, K., Takauji, Y., Kasukabe, R., Miki, K., Hossain, M. N., … & Fujii, M. (2019). Extract of Emblica officinalis enhances the growth of human keratinocytes in culture. Journal of integrative medicine.
Human Bladder Epithelial Cells: HBlEpC
Kim, D., Ahn, B. N., Kim, Y., Hur, D. Y., Yang, J. W., Park, G. B., … & Kim, M. K. (2019). High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. Journal of diabetes research, 2019.
Human Carotid Artery Endothelial Cells: HCtAEC
Pott, G. B., Tsurudome, M., Proctor, L. L., & Goalstone, M. L. (2019). CIGARETTE SMOKE EXTRACT, KALLIKREIN-6 AND APROTININ REGULATE PRODUCTION OF SOLUBLE VCAM-1 AND ICAM-1 IN HUMAN CAROTID ENDOTHELIAL CELLS.
Human Dermal Fibroblasts: HDF
Desai, D., Lauver, M. D., Cruz, L., Jin, G., Ferguson, K., Roper, B., … & Buchkovich, N. J. (2019). Inhibition of Diverse Opportunistic Viruses by Structurally Optimized Retrograde Trafficking Inhibitors. Bioorganic & Medicinal Chemistry.
Human Mammary Epithelial Cells: HMEpC
Fukui, T., Soda, K., Takao, K., & Rikiyama, T. (2019). Extracellular spermine activates DNA methyltransferase 3A and 3B. International journal of molecular sciences, 20(5), 1254.
Rat Aortic Endothelial Cells: RAOEC
Naik, J. S., & Walker, B. R. (2018). Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels. Pflügers Archiv-European Journal of Physiology, 470(4), 633-648.
2018
Human Chondrocytes
Chen, Y.J., Chang, W.A., Wu, L.Y., Hsu, Y.L., Chen, C.H. and Kuo, P.L., 2018. Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics. Journal of Clinical Medicine, 7(12), p.535.
Bovine Aortic Endothelial Cells: BAOEC
Takahashi, A., Takahashi, M., Fujie, T., Hara, T., Yoshida, E., Yamamoto, C. and Kaji, T., 2018. A zinc complex that suppresses the expression of a reactive sulfur species-producing enzyme, cystathionine γ-lyase, in cultured vascular endothelial cells. Fundamental Toxicological Sciences, 5(6), pp.181-184.
Human Dermal Fibroblasts: HDF
Yu, C., Ma, X., Zhu, W., Wang, P., Miller, K.L., Stupin, J., Koroleva-Maharajh, A., Hairabedian, A. and Chen, S., 2018. Scanningless and continuous 3D bioprinting of human tissues with decellularized extracellular matrix. Biomaterials.
Human Umbilical Vein Endothelial Cells: HUVEC
Tan, Z. B., Fan, H. J., Wu, Y. T., Xie, L. P., Bi, Y. M., Xu, H. L., … & Zhou, Y. C. (2018). Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling. Journal of Ethnopharmacology.
Skeletal Muscle Growth Medium
Patton, J. B., Bennuru, S., Eberhard, M. L., Hess, J. A., Torigian, A., Lustigman, S., … & Abraham, D. (2018). Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. PLOS Neglected Tropical Diseases, 12(12), e0006977.
Human Chondrocytes
Tsumaki, N. and Yamashita, A., Kyoto University, 2018. Prophylactic and therapeutic agents for fgfr3 diseases and screening method for the same. U.S. Patent Application 16/059,462.
Human Dermal Fibroblasts: HDF
Playne, R., Jones, K. S., & Connor, B. (2018). Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors. J Stem Cells Regen Med.
Human Dermal Fibroblasts: HDF
Ikeda, K., Uchida, N., Nishimura, T., White, J., Martin, R.M., Nakauchi, H., Sebastiano, V., Weinberg, K.I. and Porteus, M.H., (2018). Efficient scarless genome editing in human pluripotent stem cells. Nature methods, 15(12), p.1045.
Endothelial Cell Growth Medium Leonard, J.N., Stranford, D.M. and Passineau, M.J., Northwestern University, (2018). Deliverable extracellular vesicles incorporating cell membrane transport proteins. U.S. Patent Application 15/975,222.
Human Peripheral Blood B Cells: HPBB
Marin, E.H., Paek, H., Li, M., Ban, Y., Karaga, M.K., Shashidharamurthy, R. and Wang, X., 2018. Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells. Investigational new drugs, pp.1-12.
Human Adipocyte Differentiation Medium
Bagher, Z., Kamrava, S. K., Alizadeh, R., Farhadi, M., Absalan, M., Falah, M. & Komeili, A. (2018). Differentiation of Neural Crest Stem Cells From Nasal Mucosa into Motor Neuron-Like Cells. Journal of Chemical Neuroanatomy.
MCDB 105 Medium
Starbuck, K., Al-Alem, L., Eavarone, D. A., Hernandez, S. F., Bellio, C., Prendergast, J. M., & Behrens, J. (2018). Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau. Oncotarget, 9(33), 23289.
Bovine Pulmonary Artery Endothelial cells: BPAEC
Rowan, S. C., Rochfort, K. D., Piouceau, L., Cummins, P. M., O’Rourke, M., & McLoughlin, P. (2018). Pulmonary endothelial permeability and tissue fluid balance depend on the viscosity of the perfusion solution. American Journal of Physiology-Lung Cellular and Molecular Physiology.
Human Dermal Fibroblasts: HDF
Chaudhuri, R.K., Sytheon Ltd, 2018. Skin enhancing compositions and methods. U.S. Patent Application 15/798,804.
Human Preadipocytes: HPAd
Matsubara, Yumiko, Takeru Zama, Yasuo Ikeda, Yukako Uruga, Toshio Suda, and Sahoko Matsuoka. “Method for producing megakaryocytes, platelets and/or thrombopoietin using mesenchymal cells.” U.S. Patent Application 15/815,069.
Human Aortic Smooth Muscle Cells: HAOSMC
van Engeland, N. C., Pollet, A. M., den Toonder, J. M., Bouten, C. V., Stassen, O. M., & Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab on a Chip.
Canine Osteoblasts: CnOb
Scott, M.C., Sarver, A.L., Modiano, J.F., Subramanian, S., Largaespada, D.A. and Spector, L.G., University of Minnesota, 2018. Tumor Analytical Methods. U.S. Patent Application 15/783,352.
Human Dermal Fibroblasts: HDF
Yoshida, Shunsuke, Mitsuru Inamura, Tohru Tanaka, Hiroyuki Ishikawa, and Hidenori Ito. “Stem cell removing method, differentiated cell protective method, and culture medium composition.” U.S. Patent Application 15/565,422.
Human Chondrocytes: HC
Li, A., Wei, Y., Hung, C., & Vunjak-Novakovic, G. (2018). Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials.
Human Coronary Artery Endothelial Cells: HCAEC
Xu, S., Xu, Y., Yin, M., Zhang, S., Liu, P., Koroleva, M.,..& Jin, Z. G. (2018). Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8(11), 3007-3021.
Human MesoEndo Endothelial Cell Media
Xu, S., Xu, Y., Yin, M., Zhang, S., Liu, P., Koroleva, M.,..& Jin, Z. G. (2018). Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8(11), 3007-3021.
Rat Aortic Smooth Muscle Cells: RAOSMC
Park, H. S., Han, J. H., Jung, S. H., Lee, D. H., Heo, K. S., & Myung, C. S. (2018). Anti-apoptotic effects of autophagy via ROS regulation in microtubule-targeted and PDGF-stimulated vascular smooth muscle cells. The Korean Journal of Physiology & Pharmacology, 22(3), 349-360.
Human Dermal Fibroblasts: HDF
Kikkawa, Y., Enomoto-Okawa, Y., Fujiyama, A., Fukuhara, T., Harashima, N., Sugawara, Y., … & Ito, Y. (2018). Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates. Scientific reports, 8.
Human Pulmonary Artery Smooth Muscle Cells: HPASMC
Wilson, J. L., Warburton, R., Taylor, L., Toksoz, D., Hill, N., & Polgar, P. (2018). Unraveling endothelin-1 induced hypercontractility of human pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. PloS one, 13(4), e0195780.
Human Dermal Fibroblasts: HDF
Ito, Tomohisa, Takashi Ando, Miki Suzuki-Karasaki, Tomohiko Tokunaga, Yukihiro Yoshida, Toyoko Ochiai, Yasuaki Tokuhashi, and Yoshihiro Suzuki-Karasaki. “Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL.” International Journal of Oncology.
Human Carotid Artery Endothelial Cells: HCtAEC
Hoh, B. L., Rojas, K., Lin, L., Fazal, H. Z., Hourani, S., Nowicki, K. W., … & Hosaka, K. (2018). Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin‐17A Which Downregulates E‐Cadherin. Journal of the American Heart Association, 7(8), e008863.
Anti-Phospho-VEGFR3: Rabbit VEGFR3, Phospho-Tyr1230/1231 Antibody
Sakima, M., Hayashi, H., Al Mamun, A., & Sato, M. (2018). VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells. Experimental cell research.
Human Dermal Fibroblasts: HDF
Kang, L., Liu, X., Yue, Z., Chen, Z., Baker, C., Winberg, P. C., & Wallace, G. G. (2018). Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications. Polymers, 10(4), 415.
Human Chondrocyte Media
Barrett, Carolyn, and Yaling Shi. “Cartilage mosaic compositions and methods.” U.S. Patent Application 15/608,679.
Human Dermal Fibroblasts: HDF
Esparza, Y., Bandara, N., Ullah, A., & Wu, J. (2018). Hydrogels from feather keratin show higher viscoelastic properties and cell proliferation than those from hair and wool keratins. Materials Science and Engineering: C.
Human Aortic Smooth Muscle Cells: HAOSMC
Cardenas, C. L. L., Kessinger, C. W., Cheng, Y., MacDonald, C., MacGillivray, T., Ghoshhajra, B., … & Kaminski, N. (2018). An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nature Communications, 9(1), 1009.
Human Epidermal Keratinocytes: HEK
Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., & Ohtani, N. (2018). Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nature Communications, 9(1), 1249.
Bovine Aortic Endothelial Cells: BAOEC
Zhao, X., Hui, D. S., Lee, R., & Edwards, J. L. (2018). Ratiometric quantitation of thiol metabolites using non-isotopic mass tags. Analytica Chimica Acta.
Human Endothelial Cell Growth Medium
Passineau, M.J., Murali, S., Benza, R.L. and Pollett, J.B., Allegheny-Singer Research Institute, 2018. ISOLATION OF PULMONARY ARTERIAL ENDOTHELIAL CELLS FROM PATIENTS WITH PULMONARY VASCULAR DISEASE AND USES THEREOF. U.S. Patent Application 15/806,751.
DiI-Ac-LDL Kit
Lian, W., Hu, X., Shi, R., Han, S., Cao, C., Wang, K., & Li, M. (2018). MiR-31 regulates the function of diabetic endothelial progenitor cells by targeting Satb2. Acta biochimica et biophysica Sinica.
Human Hair Follicle Dermal Papilla Cells: HFDPC
Lahiji SF, Seo SH, Kim S, Dangol M, Shim J, Li CG, Ma Y, Lee C, Kang G, Yang H, Choi KY. (2018). Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth. Biomaterials.
Bovine Aortic Endothelial Cells: BAOEC
Zhao, X., Hui, D. S., Lee, R., & Edwards, J. L. (2018). Ratiometric quantitation of thiol metabolites using non-isotopic mass tags. Analytica Chimica Acta.
Human Aortic Smooth Muscle Cells: HAOSMC
Cardenas, C. L. L., Kessinger, C. W., MacDonald, C., Jassar, A. S., Isselbacher, E. M., Jaffer, F. A., & Lindsay, M. E. (2018). Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI insight, 3(5).
Endothelial Cell Growth Medium
CD Nichols, B YU (2018). LOW DOSAGE SEROTONIN 5-HT2A RECEPTOR AGONIST TO SUPPRESS INFLAMMATION. US Patent App. 15/478,437.
Rat Brain Microvascular Endothelial Cells: RBMVEC
Brailoiu, E., Barlow, C. L., Ramirez, S. H., Abood, M. E., & Brailoiu, G. C. (2018). Effects of Platelet-Activating Factor on brain microvascular endothelial cells. Neuroscience.
Human Carotid Artery Smooth Muscle Cells: HCtASMC
Han, X., Sakamoto, N., Tomita, N., Meng, H., Sato, M., & Ohta, M. (2017). Influence of shear stress on phenotype and MMP production of smooth muscle cells in a co-culture model. Journal of Biorheology, 31(2), 50-56.
Human Fibroblast-Like Synoviocytes: HFLS
Yu, R., Li, C., Sun, L., Jian, L., Ma, Z., Zhao, J., & Liu, X. (2018). Hypoxia induces production of citrullinated proteins in human fibroblast‐like synoviocytes through regulating HIF1α. Scandinavian journal of immunology.
Human Cardiac Fibroblasts: HCF
John, C.M., Meenakshi, G.A.U.R., Matthew, L. and Wang, X., MANDALMED Inc, 2018. Methods and compositions for preventing and treating damage to the heart. U.S. Patent Application 15/666,456.
Rat Smooth Muscle Cell Media
Chinnappan, M., Mohan, A., Agarwal, S., Dalvi, P., & Dhillon, N. K. (2018). Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor‐2: Involvement in HIV‐Associated Pulmonary Vascular Remodeling. Journal of the American Heart Association, 7(5), e008472.
Human Smooth Muscle Cell Growth Medium
Cardenas, C. L. L., Kessinger, C. W., MacDonald, C., Jassar, A. S., Isselbacher, E. M., Jaffer, F. A., & Lindsay, M. E. (2018). Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI insight, 3(5).
Human Fibroblast-Like Synoviocytes: HFLS
Rosa, I., Marini, M., Guasti, D., Ibba-Manneschi, L., & Manetti, M. (2018). Morphological evidence of telocytes in human synovium. Scientific reports, 8(1), 3581.
Human Carotid Artery Endothelial Cells: HCtAEC
Han, X., Sakamoto, N., Tomita, N., Meng, H., Sato, M., & Ohta, M. (2017). Influence of shear stress on phenotype and MMP production of smooth muscle cells in a co-culture model. Journal of Biorheology, 31(2), 50-56.
Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis: HFLS-RA
Hagihara, M., Shimizu, M. and Wada, Y., Ube Industries Ltd, 2018. Method of producing substance. U.S. Patent Application 15/545,624.
Bovine Aortic Endothelial Cells: BAOEC
Uhl, C. G., Gao, Y., Zhou, S., & Liu, Y. (2018). The shape effect on polymer nanoparticle transport in a blood vessel. RSC Advances, 8(15), 8089-8100.
Human Umbilical Vein Endothelial Cells: HUVEC
Sasahira, T., Nishiguchi, Y., Kurihara-Shimomura, M., Nakashima, C., Kuniyasu, H., & Kirita, T. (2018). NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. Journal of cancer research and clinical oncology, 1-8.
Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis: HFLS-RARhys, H. I., Dell’Accio, F., Pitzalis, C., Moore, A., Norling, L. V., & Perretti, M. (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine.
Rabbit Aortic Smooth Muscle Cells: RbAOSMC
Honda, K., Matoba, T., Antoku, Y., Koga, J. I., Ichi, I., Nakano, K., & Egashira, K. (2018). Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque ErosionHighlights: A Role of Serum Oxysterols. Arteriosclerosis, thrombosis, and vascular biology, 38(4), 757-771.
Human Dermal Fibroblasts: HDF
Tokunaga, T., Ando, T., Suzuki-Karasaki, M., Ito, T., Onoe-Takahashi, A., Ochiai, T., Soma, M. and Suzuki-Karasaki, Y., 2018. Plasma-stimulated medium kills TRAIL-resistant human malignant cells by promoting caspase-independent cell death via membrane potential and calcium dynamics modulation. International journal of oncology, 52(3), pp.697-708.
Human Coronary Artery Endothelial Cells RNA
Baggio, L. L., Yusta, B., Mulvihill, E. E., Cao, X., Streutker, C. J., Butany, J., & Drucker, D. J. (2018). GLP-1 receptor expression within the human heart. Endocrinology, 159(4), 1570-1584.
Human Coronary Artery Endothelial Cells: HCAEC
Qiao, C., Li, S., Lu, H., Meng, F., Fan, Y., Guo, Y., Chen, Y.E. and Zhang, J., 2018. Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells. Scientific reports, 8(1), p.2360.
Human Endothelial Cell Growth Medium
Chia-Hung Chou, Chi-Sheng Hung, Che-Wei Liao, Lin-Hung Wei, Ching-Way Chen, Chia-Tung Shun, Wen-Fen Wen, Cho-Hua Wan, Xue-Ming Wu, Yi-Yao Chang, Vin-Cent Wu, Kwan-Dun Wu, Yen-Hung Lin, The TAIPAI Study Group; 2018. IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. Cardiovascular Research, Volume 114, Issue 5, Pages 690–702.
Rat Dermal Fibroblasts: RDF
Grunlan, M.A., Cote, G.L., Abraham, A.A., Fei, R. and Locke, A.K., Texas A&M University System, 2018. Self-Cleaning Membrane for Medical Devices. U.S. Patent Application 15/545,811.
Bovine Aortic Smooth Muscle Cells: BAOSMC
Tsukagoshi, T., Nguyen, T. V., Shoji, K. H., Takahashi, H., Matsumoto, K., & Shimoyama, I. (2018). Cellular dynamics of bovine aortic smooth muscle cells measured using MEMS force sensors. Journal of Physics D: Applied Physics, 51(14), 145401.
Rat Fibroblast Growth Medium
Grunlan, M.A., Cote, G.L., Abraham, A.A., Fei, R. and Locke, A.K., Texas A&M University System, 2018. Self-Cleaning Membrane for Medical Devices. U.S. Patent Application 15/545,811.
Human Umbilical Vein Endothelial Cells: HUVEC
Gaston, B.M., Straub, A.C., Isakson, B.E. and Columbus, L., University of Virginia Licensing and Ventures Group, 2018. Compositions and methods for regulating arterial tone. U.S. Patent Application 15/643,633.
Rat Aortic Endothelial Cells: RAOEC
Naik, J.S. and Walker, B.R., 2018. Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels. Pflügers Archiv-European Journal of Physiology, pp.1-16.
Human Fibroblast-Like Synoviocytes: HFLS
Hagihara, M., Shimizu, M. and Wada, Y., Ube Industries Ltd, 2018. Method of producing substance. U.S. Patent Application 15/545,624.
Human Preadipocytes: HPAd
Oishi, T., Sakata, A., Shishido, M. and Hirakawa, S., A serum protein, an unexpected player inducing the skin sagging, and a proposed measure for improving the facial sagging.
Human Adipocyte Differentiation Medium Oishi, T., Sakata, A., Shishido, M. and Hirakawa, S., A serum protein, an unexpected player inducing the skin sagging, and a proposed measure for improving the facial sagging.
Human Umbilical Vein Smooth Muscle Cells: HUVSMC
Gaston, B.M., Straub, A.C., Isakson, B.E. and Columbus, L., University of Virginia Licensing and Ventures Group, 2018. Compositions and methods for regulating arterial tone. U.S. Patent Application 15/643,633.
Rat Aortic Endothelial Cells: RAOEC
Iba, T., Hirota, T., Sato, K. and Nagaoka, I., 2018. Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage. International Journal of Hematology, pp.1-7.
Human Dermal Fibroblasts: HDF
Ito, N., Katoh, K., Kushige, H., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T. and Araki, N., 2018. Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency. Scientific reports, 8(1), p.1634.
Human dermal fibroblast growth medium
Ito, N., Katoh, K., Kushige, H., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T. and Araki, N., 2018. Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency. Scientific reports, 8(1), p.1634.
Human Dermal Fibroblasts: HDF
Martin, R., Ikeda, K., Uchida, N., Cromer, M.K., Nishimura, T., Dever, D.P., Camarena, J., Bak, R., Lausten, A., Jakobsen, M.R. and Wiebking, V., 2018. Selection-free, high frequency genome editing by homologous recombination of human pluripotent stem cells using Cas9 RNP and AAV6. bioRxiv, p.252163.
DiI-Ac-LDL Kit
Iba, T., Hirota, T., Sato, K. and Nagaoka, I., 2018. Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage. International Journal of Hematology, pp.1-7.
Rat cardiac fibroblasts
Fan, Z., Xu, Z., Niu, H., Gao, N., Guan, Y., Li, C., Dang, Y., Cui, X., Liu, X.L., Duan, Y. and Li, H., 2018. An
Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction. Scientific Reports, 8(1), p.1371.
Human Umbilical Vein Endothelial Cells: HUVEC
Chia-Hung Chou, Chi-Sheng Hung, Che-Wei Liao, Lin-Hung Wei, Ching-Way Chen, Chia-Tung Shun, Wen-Fen Wen, Cho-Hua Wan, Xue-Ming Wu, Yi-Yao Chang, Vin-Cent Wu, Kwan-Dun Wu, Yen-Hung Lin, The TAIPAI Study Group; 2018. IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. Cardiovascular Research, Volume 114, Issue 5, Pages 690–702.
Human Dermal Fibroblasts: HDF
Ishida, K., Xu, H., Sasakawa, N., Lung, M.S.Y., Kudryashev, J.A., Gee, P. and Hotta, A., 2018. Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells. Scientific reports, 8(1), p.310.
Human Coronary Artery Endothelial Cells: HCAEC
Hwang, H.V., Tran, D.T., Rebuffatti, M.N., Li, C.S. and Knowlton, A.A., 2018. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PloS one, 13(1), p.e0190374.
Human Epidermal Keratinocytes: HEK
Qiao, M., Li, R., Zhao, X., Yan, J. and Sun, Q., 2018. Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7. Experimental cell research.
2017
Human Umbilical Vein Endothelial Cells: HUVEC
Izzicupo, P., D’Amico, M.A., Di Blasio, A., Napolitano, G., Nakamura, F.Y., Di Baldassarre, A. and Ghinassi, B., 2017. Aerobic Training Improves Angiogenic Potential Independently of VEGF Modifications in Postmenopausal Women. Frontiers in Endocrinology, 8, p.363.
Human Dermal Fibroblasts: HDF
Ohta, K. and Ito, N., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, 2017. METHOD FOR INDUCING CELL REPROGRAMMING, AND METHOD FOR PRODUCING PLURIPOTENT CELLS. U.S. Patent Application 15/310,189.
Human Pulmonary Artery Smooth Muscle Cells: HPASMC
Nadeau, V., Potus, F., BOUCHERAT, O., Paradis, R., Tremblay, E., Iglarz, M., PAULIN, R., Bonnet, S. and PROVENCHER, S., 2017. Dual eta/etb blockade with macitentan improves both vascular remodelling and angiogenesis in pulmonary arterial hypertension. Pulmonary Circulation, p.2045893217741429.
Bovine Pulmonary Artery Endothelial Cells: BPAEC
Frawley, Kristin L., Andrea A. Cronican, Linda Lorraine Pearce, and Jim Peterson., 2017. Sulfide Toxicity and Its Modulation by Nitric Oxide in Bovine Pulmonary Artery Endothelial Cells. Chemical Research in Toxicology (2017).
Classical Cell Media: MCDB-105
He, S., Deng, Y., Liao, Y., Li, X., Liu, J. and Yao, S., 2017. CREB5 promotes tumor cell invasion and correlates with poor prognosis in epithelial ovarian cancer. Oncology Letters, 14(6), pp.8156-8161.
Bovine Brain Endothelial Cell Growth Medium
Duck, K.A., Simpson, I.A. and Connor, J.R., 2017. Regulatory mechanisms for iron transport across the blood-brain barrier. Biochemical and Biophysical Research Communications.
Human Osteoblast Growth Medium
Chen, Y.J., Chang, W.A., Hsu, Y.L., Chen, C.H. and Kuo, P.L., 2017. Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches. International Journal of Molecular Sciences, 18(11), p.2396.
Bovine Insulin
Buckner, S., Pruitt, A., Thomas, C., Amin, M., Miller, L., Wiley, F. and Sabbatini, M.E., 2017. Di-N-octylphthalate acts as a proliferative agent in murine cell hepatocytes by regulating the levels of TGF-β and pro-apoptotic proteins. Food and Chemical Toxicology.
Bovine Aortic Endothelial Cells: BAOEC
Nakamura, T., Yoshida, E., Fujie, T., Ogata, F., Yamamoto, C., Kawasaki, N. and Kaji, T., 2017. Synergistic cytotoxicity caused by forming a complex of copper and 2, 9-dimethyl-1, 10-phenanthroline in cultured vascular endothelial cells. The Journal of Toxicological Sciences, 42(6), pp.683-687.
Human Preadipocytes: HPAd
Zahid, H., Subbaramaiah, K., Iyengar, N.M., Zhou, X.K., Chen, I.C., Bhardwaj, P., Gucalp, A., Morrow, M., Hudis, C.A., Dannenberg, A.J. and Brown, K.A., 2017. Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells—a novel mechanism for the obesity-breast cancer link. International Journal of Obesity. DOI: 10.1038/ijo.2017.273.
Human Pulmonary Artery Endothelial Cells: HPAEC
Nadeau, V., Potus, F., BOUCHERAT, O., Paradis, R., Tremblay, E., Iglarz, M., PAULIN, R., Bonnet, S. and PROVENCHER, S., 2017. Dual eta/etb blockade with macitentan improves both vascular remodelling and angiogenesis in pulmonary arterial hypertension. Pulmonary Circulation, p.2045893217741429.
Human Coronary Artery Endothelial Cells: HCAEC
Rai, R., Ghosh, A.K., Eren, M., Mackie, A.R., Levine, D.C., Kim, S.Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L.H. and Woodruff, T.K., 2017. Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan. Cell Reports, 21(6), pp.1471-1480.
MesoEndo Medium
Izadifar, M., Chapman, D., Babyn, P., Chen, X. and Kelly, M.E., 2017. UV-assisted 3D bioprinting of nano-reinforced hybrid cardiac patch for myocardial tissue engineering. Tissue Engineering, Part C Methods.
Human Cardiac Fibroblasts: HCF
Van Linthout, S., Hamdani, N., Miteva, K., Koschel, A., Müller, I., Pinzur, L., Aberman, Z., Pappritz, K., Linke, W.A. and Tschöpe, C., 2017. Placenta‐Derived Adherent Stromal Cells Improve Diabetes Mellitus‐Associated Left Ventricular Diastolic Performance. Stem cells translational medicine.
Bovine Brain Microvascular Endothelial Cells: BBMVEC
Duck, K.A., Simpson, I.A. and Connor, J.R., 2017. Regulatory mechanisms for iron transport across the blood-brain barrier. Biochemical and Biophysical Research Communications.
Human Preadipocyte Growth Medium
Zahid, H., Subbaramaiah, K., Iyengar, N.M., Zhou, X.K., Chen, I.C., Bhardwaj, P., Gucalp, A., Morrow, M., Hudis, C.A., Dannenberg, A.J. and Brown, K.A., 2017. Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells—a novel mechanism for the obesity-breast cancer link. International Journal of Obesity. DOI: 10.1038/ijo.2017.273.
Human Peripheral Blood Mononuclear Cells: PBMC/HMNC-PB
Totani, T. and Tanaka, S., TOYO SEIKAN GROUP HOLDINGS, LTD., 2017. CULTURE CONTAINER AND METHOD FOR MANUFACTURING CULTURE CONTAINER. U.S. Patent 20,170,283,758.
Human Osteoblasts: Rheumatoid Arthritis: HOb-RA
Chen, Y.J., Chang, W.A., Hsu, Y.L., Chen, C.H. and Kuo, P.L., 2017. Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches. International Journal of Molecular Sciences, 18(11), p.2396.
Anti-ERα 36 Ab
Yan, Y., Yu, L., Castro, L. and Dixon, D., 2017. ERα36, a variant of estrogen receptor α, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells. PloS one, 12(10), p.e0186078.
Human Microvascular Endothelial Cell Media
Wu, Y., Zhang, Q. and Zhang, R., 2017. Kaempferol targets estrogen‑related receptor α and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions. Experimental and Therapeutic Medicine, 14(6), pp.5576-5582.
Human Lung Microvascular Endothelial Cells: HLMVEC
Iyer, R., Harris, J.F., Huang, J.H., Nath, P. and Przekwas, A., Los Alamos National Security, LLC, 2017. MULTI-ORGAN MEDIA COMPOSITIONS AND METHODS OF THEIR USE. U.S. Patent 20,170,275,587.
Classical Cell Media: MCDB-105
He, S., Niu, G., Shang, J., Deng, Y., Wan, Z., Zhang, C., You, Z. and Shen, H., 2017. The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway. Journal of Experimental & Clinical Cancer Research, 36(1), p.137.
Human Umbilical Vein Endothelial Cells: HUVEC
Cao, X., Han, C., Wen, J., Guo, X. and Zhang, K., 2017. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and Experimental Pharmacology and Physiology.
Human Endothelial Cell Defined Medium
Rai, R., Ghosh, A.K., Eren, M., Mackie, A.R., Levine, D.C., Kim, S.Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L.H. and Woodruff, T.K., 2017. Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan. Cell Reports, 21(6), pp.1471-1480.
MesoEndo Medium
Zhou, T. and Chen, X., 2017. Long intergenic noncoding RNA p21 mediates oxidized LDL‑induced apoptosis and expression of LOX‑1 in human coronary artery endothelial cells. Molecular Medicine Reports, 16(6), pp.8513-8519.
Human Smooth Muscle Cell Media
Nadeau, V., Potus, F., BOUCHERAT, O., Paradis, R., Tremblay, E., Iglarz, M., PAULIN, R., Bonnet, S. and PROVENCHER, S., 2017. Dual eta/etb blockade with macitentan improves both vascular remodelling and angiogenesis in pulmonary arterial hypertension. Pulmonary Circulation, p.2045893217741429.
Anti-CD133
Choi, Y., Park, J., San Ko, Y., Kim, Y., Pyo, J.S., Jang, B.G., Kim, M.A., Lee, J.S., Chang, M.S. and Lee, B.L., 2017. FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells. Biochemical and Biophysical Research Communications, 493(3), pp.1349-1355.
Human Cardiac Fibroblast Basal Medium
Van Linthout, S., Hamdani, N., Miteva, K., Koschel, A., Müller, I., Pinzur, L., Aberman, Z., Pappritz, K., Linke, W.A. and Tschöpe, C., 2017. Placenta‐Derived Adherent Stromal Cells Improve Diabetes Mellitus‐Associated Left Ventricular Diastolic Performance. Stem cells translational medicine.
Human Umbilical Vein Endothelial Cells: HUVEC
Chen, X., Duong, M.N., Psaltis, P.J., Bursill, C.A. and Nicholls, S.J., 2017. High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes. Cardiovascular diabetology, 16(1), p.121.
Human Coronary Artery Endothelial Cells: HCAEC
Izadifar, M., Chapman, D., Babyn, P., Chen, X. and Kelly, M.E., 2017. UV-assisted 3D bioprinting of nano-reinforced hybrid cardiac patch for myocardial tissue engineering. Tissue Engineering, Part C Methods.
Rat Neural Stem Cell Differentiation Media
Hwang, M., Park, H.H., Choi, H., Lee, K.Y., Lee, Y.J. and Koh, S.H., 2017. Effects of aspirin and clopidogrel on neural stem cells. Cell Biology and Toxicology, pp.1-14.
Bovine Insulin
Zheng, Q., Bai, L., Zheng, S., Liu, M., Zhang, J., Wang, T., Xu, Z., Chen, Y., Li, J. and Duan, Z., 2017. Efficient inhibition of duck hepatitis B virus DNA by the CRISPR/Cas9 system. Molecular Medicine Reports, 16(5), pp.7199-7204.
Anti-ERα 36 Ab
Dai, Y.J., Qiu, Y.B., Jiang, R., Xu, M., Zhao, L., Chen, G.G. and Liu, Z.M., 2017. Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas. Scientific Reports, 7(1), p.12279.
Human Umbilical Vein Endothelial Cells: HUVEC
Baimakhanov, Z., Sakai, Y., Yamanouchi, K., Hidaka, M., Soyama, A., Takatsuki, M. and Eguchi, S., 2017. Spontaneous hepatocyte migration towards an endothelial cell tube network. Journal of Tissue Engineering and Regenerative Medicine.
Rat Brain Microvascular Endothelial Cells: RBMVEC
Velasco-Aguirre, C., Morales-Zavala, F., Salas-Huenuleo, E., Gallardo-Toledo, E., Andonie, O., Muñoz, L., Rojas, X., Acosta, G., Sánchez-Navarro, M., Giralt, E. and Araya, E., 2017. Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2. Nanomedicine, 12(20), pp.2503-2517.
Attachment Factor Solution
Ruderisch, N., Schlatter, D., Kuglstatter, A., Guba, W., Huber, S., Cusulin, C., Benz, J., Rufer, A.C., Hoernschemeyer, J., Schweitzer, C. and Bülau, T., 2017. Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24, pp.76-92.
Human Smooth Muscle Cell Growth Medium
Yu, H., Jia, Q., Feng, X., Chen, H., Wang, L., Ni, X. and Kong, W., 2017. Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells. The International Journal of Biochemistry & Cell Biology, 91, pp.37-44.
Anti-CD133
Cho, Y.C., Nguyen, T.T., Park, S.Y., Kim, K., Kim, H.S., Jeong, H.G., Kim, K.K. and Kim, H., 2017. Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. International Journal of Molecular Sciences, 18(9), p.1888.
Human Coronary Artery Endothelial Cells: HCAEC
Zhou, T. and Chen, X., 2017. Long intergenic noncoding RNA p21 mediates oxidized LDL‑induced apoptosis and expression of LOX‑1 in human coronary artery endothelial cells. Molecular Medicine Reports, 16(6), pp.8513-8519.
Human Umbilical Vein Endothelial Cells: HUVEC
Lai, C.J., Cheng, H.C., Lin, C.Y., Huang, S.H., Chen, T.H., Chung, C.J., Chang, C.H., Wang, H.D. and Chuu, C.P., 2017. Activation of liver X receptor suppresses angiogenesis via induction of ApoD. The FASEB Journal, pp.fj-201700374R.
Human Osteoblasts: HOb
Chen, Y.J., Chang, W.A., Hsu, Y.L., Chen, C.H. and Kuo, P.L., 2017. Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches. International Journal of Molecular Sciences, 18(11), p.2396.
Human Aortic Endothelial Cells: HAOEC
Lo, W. Y., Peng, C. T., & Wang, H. J. (2017). MicroRNA-146a-5p Mediates High Glucose-Induced Endothelial Inflammation via Targeting Interleukin-1 Receptor-Associated Kinase 1 Expression. Frontiers in Physiology, 8, 551.
Human Chondrocytes: HC
Bellayr, I.H., Kumar, A. and Puri, R.K., 2017. MicroRNA expression in bone marrow-derived human multipotent Stromal cells. BMC Genomics, 18(1), p.605.
Rat aortic smooth muscle cells (RASMC)
Chuang, T.D. and Khorram, O., 2017. Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms. Life Sciences, 186, pp.87-91.
Human Pulmonary Artery Smooth Muscle Cells: HPASMC
Chakraborti, S., Sarkar, J., Bhuyan, R. and Chakraborti, T., 2017. Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells. Molecular and Cellular Biochemistry, pp.1-13.
Human Mesenchymal Stem Cells: HMSC
Janda, C.Y., Dang, L.T., You, C., Chang, J., De Lau, W., Zhong, Z.A., Yan, K.S., Marecic, O., Siepe, D., Li, X. and Moody, J.D et al. 2017. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature, 545(7653), pp.234-237.
Human Aortic Smooth Muscle Cells: HAOSMC
Jiang, W., Wang, Z., Hu, Z., Wu, H., Hu, R., Hu, X., Ren, Z. and Huang, J., 2017. Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage. Cell Biology International. DOI: 10.1002/cbin.10840
Human Pulmonary Artery Smooth Muscle Cells: HPASMC
Chakraborti, S., Sarkar, J., Chowdhury, A. and Chakraborti, T., 2017. Role of ADP ribosylation factor6− Cytohesin1− PhospholipaseD signaling axis in U46619 induced activation of NADPH oxidase in pulmonary artery smooth muscle cell membrane. Archives of Biochemistry and Biophysics. DOI: 10.1016/j.abb.2017.08.012
Human Dermal Fibroblasts: HDF
Bellayr, I.H., Kumar, A. and Puri, R.K., 2017. MicroRNA expression in bone marrow-derived human multipotent Stromal cells. BMC Genomics, 18(1), p.605.
Human Endothelial Cell Growth Medium
Lo, W. Y., Peng, C. T., & Wang, H. J. (2017). MicroRNA-146a-5p Mediates High Glucose-Induced Endothelial Inflammation via Targeting Interleukin-1 Receptor-Associated Kinase 1 Expression. Frontiers in Physiology, 8, 551.
Rat Dermal Fibroblasts: RDF
Uchinaka A, Kawaguchi N, Ban T, Hamada Y, Mori S, Maeno Y, Sawa Y, Nagata K, Yamamoto H. 2017. Evaluation of dermal wound healing activity of synthetic peptide SVVYGLR. Biochem Biophys Res Commun. 2017 Jul 24. pii: S0006-291X(17)31482-1.
Endothelial Cell Growth Media Kit
Y Xue, CS Hilaire, L Hortells, JA Phillippi, V Sant, S Sant. 2017. Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture. Cellular and Molecular Bioengineering, 1-18.
Human Mesenchymal Stem Cells: HMSC
Bellayr, I.H., Kumar, A. and Puri, R.K., 2017. MicroRNA expression in bone marrow-derived human multipotent Stromal cells. BMC Genomics, 18(1), p.605.
MesoEndo Medium
Izadifar M, Babyn P, Kelly ME, Chapman D, Chen X. 2017. Bioprinting pattern-dependent electrical/mechanical behavior of cardiac alginate implants: characterization and ex-vivo phase-contrast microtomography assessment. Tissue Eng Part C Methods. doi: 10.1089/ten.TEC.2017.0222.
Osteogenic and Adipogenic Canine Differentiation Media
Matsuda, T., Takami, T., Sasaki, R., Nishimura, T., Aibe, Y., Paredes, B. D., Quintanilha, L. F., Matsumoto, T., Ishikawa, T., Yamamoto, N., Tani, K., Terai, S., Taura, Y. and Sakaida, I. 2017. A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow-derived cells. Hepatology Communications. doi:10.1002/hep4.1071.
Human Coronary Artery Endothelial Cells: HCAEC
Izadifar M, Babyn P, Kelly ME, Chapman D, Chen X. 2017. Bioprinting pattern-dependent electrical/mechanical behavior of cardiac alginate implants: characterization and ex-vivo phase-contrast microtomography assessment. Tissue Eng Part C Methods. doi: 10.1089/ten.TEC.2017.0222.
Bovine Insulin
Luchun Li, Yan Li, Lulu Wang, Zhijuan Wu, Huiwen Ma, Jianghe Shao, Dairong Li, Huiqing Yu, Weiqi Nian, Donglin Wang. 2017. Inhibition of Hes1 enhances lapatinib sensitivity in gastric cancer sphere-forming cells. Oncology Letters. https://doi.org/10.3892/ol.2017.6683.
Human Osteoblasts: Hob
Bellayr, I.H., Kumar, A. and Puri, R.K., 2017. MicroRNA expression in bone marrow-derived human multipotent Stromal cells. BMC Genomics, 18(1), p.605.
Rat Hippocampal Neurons: RHiN
McDonough Patrick M., Prigozhina Natalie L., Basa Ranor C.B., and Price Jeffrey H. 2017. Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment. ASSAY and Drug Development Technologies. 15(5): 220-236.
Human Dermal Fibroblasts: HDF
Y Esparza, A Ullah, Y Boluk, J Wu. 2017. Preparation and characterization of thermally crosslinked poly (vinyl alcohol)/feather keratin nanofiber scaffolds. Materials & Design, https://doi.org/10.1016/j.matdes.2017.07.052.
Canine Osteoblasts: CnOb
Troyer RM, Ruby CE, Goodall CP, Yang L, Maier CS, Albarqi HA, Brady JV, Bathke K, Taratula O, Mourich D, Bracha S. 2017. Exosomes from Osteosarcoma and normal osteoblast differ in proteomic cargo and immunomodulatory effects on T cells. Exp Cell Res. pii: S0014-4827(17)30365-8.
Human Carotid Artery Endothelial Cells: HCtAEC
Pott, G. B., Tsurudome, M., Bui, J., Banfield, C., Hourieh, S., Pratap, H., & Goalstone, M. L. 2017. VCAM-1 Mediates Cigarette Smoke Extract Enhancement of Monocyte Adhesion to Human Carotid Endothelial Cells. Medical Research Archives. Volume 5, issue 7.
Human Umbilical Vein Endothelial Cells: HUVEC
Goszcz, K., Deakin, S., Duthie, G. G., Stewart, D., Megson, I. L., & Megson, I. L. 2017. Bioavailable concentrations of delphinidin and its metabolite, gallic acid, induce antioxidant protection associated with increased intracellular glutathione in cultured endothelial cells. Oxidative Medicine and Cellular Longevity.
Rat Endothelial Cell Basal Medium
Iba, T., Sasaki, T., Ohshima, K., Sato, K., Nagaoka, I., Thachil, J., Bucur, S.Z., Levy, J.H., Despotis, G.J., Spiess, B.D. and Hillyer, C.D., 2017. The comparison of the protective effects of α-and β-antithrombin against vascular endothelial cell damage induced by histone in vitro. TH Open, 1(01), pp.e3-e10.
Human Dermal Fibroblasts: HDF
Martinez-Cerdeno, Veronica, Bonnie Barrilleaux, Ashley McDonough, Jeanelle Ariza, Benjamin Yuen, Priyanka Somanath, Catherine Le, Craig Steward, Kayla Horton, and Paul Knoepfler. 2017. Behavior of xeno-transplanted undifferentiated human induced pluripotent stem cells is impacted by microenvironment without evidence of tumors. Stem Cells and Development. https://doi.org/10.1089/scd.2017.0059.
Anti-CD133
Phiboonchaiyanan, P.P. and Chanvorachote, P., 2017. Suppression of a cancer stem-like phenotype mediated by alpha-lipoic acid in human lung cancer cells through down-regulation of β-catenin and Oct-4. Cellular Oncology, pp.1-14.
Bovine Aortic Endothelial Cells: BAOEC
Dang, L.T., Aburatani, T., Marsh, G.A., Johnson, B.G., Alimperti, S., Yoon, C.J., Huang, A., Szak, S., Nakagawa, N., Gomez, I. and Ren, S., 2017. Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury. Biomaterials. https://doi.org/10.1016/j.biomaterials.2017.07.010
Rat Aortic Endothelial Cells: RAOEC
Iba, T., Sasaki, T., Ohshima, K., Sato, K., Nagaoka, I., Thachil, J., Bucur, S.Z., Levy, J.H., Despotis, G.J., Spiess, B.D. and Hillyer, C.D., 2017. The comparison of the protective effects of α-and β-antithrombin against vascular endothelial cell damage induced by histone in vitro. TH Open, 1(01), pp.e3-e10.
Human Smooth Muscle Cell Media
Vanags, L.Z., Tan, J.T., Santos, M., Michael, P.S., Ali, Z., Bilek, M.M., Wise, S.G. and Bursill, C.A., 2017. Plasma activated coating immobilizes apolipoprotein AI to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2017.06.012.
Bovine Aortic Endothelial Cells: BAOEC
Berger, A.J., Linsmeier, K., Kreeger, P.K. and Masters, K.S., 2017. Decoupling the effects of stiffness and fiber density on cellular behaviors via an interpenetrating network of gelatin-methacrylate and collagen. Biomaterials. https://doi.org/10.1016/j.biomaterials.
Human Adipocyte Differentiation Medium
Dong, Y., Betancourt, A., Belfort, M. and Yallampalli, C., 2017. Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2017-00920.
Human Umbilical Vein Smooth Muscle Cells: HUVSMC
Vanags, L.Z., Tan, J.T., Santos, M., Michael, P.S., Ali, Z., Bilek, M.M., Wise, S.G. and Bursill, C.A., 2017. Plasma activated coating immobilizes apolipoprotein AI to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology and Medicine. https://doi.org/10.1016/j.nano.2017.06.012.
Rat Brain Microvascular Endothelial Cells: RBMVEC
Gray, S.M., Aylor, K.W. and Barrett, E.J., 2017. Unravelling the regulation of insulin transport across the brain endothelial cell. Diabetologia, pp.1-10.
HOb medium
Canal, C., Fontelo, R., Hamouda, I., Guillem-Marti, J., Cvelbar, U. and Ginebra, M.P., 2017. Plasma-induced selectivity in bone cancer cells death. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2017.05.023.
Human Dermal Microvascular Endothelial Cells: CADMEC/HMVEC
Tan, W., Wang, J., Zhou, F., Gao, L., Rong, Y., Liu, H., Sukanthanag, A., Wang, G., Mihm, M.C., Chen, D.B. and Nelson, J.S., 2017. Coexistence of EphB1 and EphrinB2 in Port Wine Stain Endothelial Progenitor Cells Contributes to Clinicopathological Vasculature Dilatation. British Journal of Dermatology. DOI: 10.1111/bjd.15716.
Human Mesenchymal Stem Cell Media
Bellayr, I.H., Kumar, A. and Puri, R.K., 2017. MicroRNA expression in bone marrow-derived human multipotent Stromal cells. BMC Genomics, 18(1), p.605.
Human Endothelial Cell Media
Tan, W., Wang, J., Zhou, F., Gao, L., Rong, Y., Liu, H., Sukanthanag, A., Wang, G., Mihm, M.C., Chen, D.B. and Nelson, J.S., 2017. Coexistence of EphB1 and EphrinB2 in Port Wine Stain Endothelial Progenitor Cells Contributes to Clinicopathological Vasculature Dilatation. British Journal of Dermatology. DOI: 10.1111/bjd.15716.
Human Chondrocytes: Osteoarthritis: HC-OA
Rosenberg, J.H., Rai, V., Dilisio, M.F., Sekundiak, T.D. and Agrawal, D.K., 2017. Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint. Molecular and Cellular Biochemistry, pp.1-11.
Human Endothelial Cell Media
Shatanawi, A. and Momani, M.S., 2017. Plasma arginase activity is elevated in type 2 diabetic patients. Biomedical Research, 28(9).
Smooth Muscle Cells
Kikuchi, S., Chen, L., Xiong, K., Saito, Y., Azuma, N., Tang, G., Sobel, M., Wight, T.N. and Kenagy, R.D., 2017. Smooth muscle cells of human veins show an increased response to injury at valve sites. Journal of Vascular Surgery. http://dx.doi.org/10.1016/j.jvs.2017.03.447.
Human Osteoblasts: HOb
Canal, C., Fontelo, R., Hamouda, I., Guillem-Marti, J., Cvelbar, U. and Ginebra, M.P., 2017. Plasma-induced selectivity in bone cancer cells death. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2017.05.023.
Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis: HFLS-RA
Wang, S., Liang, S., Zhao, X., He, Y. and Qi, Y., 2017. Propofol inhibits cell proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes via the nuclear factor-κB pathway. American journal of translational research, 9(5), p.2429.
Bovine Aortic Endothelial Cells: BAOEC
Shatanawi, A. and Momani, M.S., 2017. Plasma arginase activity is elevated in type 2 diabetic patients. Biomedical Research, 28(9).
Sirimangkalakitti, N., S. Chamni, K. Suwanboriu and P. Chanvorachote. 2017. Renieramycin M Attenuates Cancer Stem Cell-like Phenotypes in H460 Lung Cancer Cells. Anticancer Research, 37:615-621.
Bailey, E., Y Cui, A. Casey, J. Stoler, X. AI, D. Ma, R. Handin, P. Sliz, S. Vargas and S. El-Chemaly. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol, 187:25-32.
Bailey, E., Y Cui, A. Casey, J. Stoler, X. AI, D. Ma, R. Handin, P. Sliz, S.Vargas and S. El-Chemaly. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol, 187:25-32.
Murakami, J., M. shii, F. Suehiro, K. Ishihata, N. Nakamura, M. Nishimura. 2017. Vascular endothelial growth factor-C induces osteogenic differentiation of human mesenchymal stem cells through the ERK and RUNX2 pathway. BBRC, dx.doi.org/10.1016/j.bbrc.2017.02.001
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
Bovine Aortic Endothelial Cells: BAOEC
Hara, T., E. Yoshida, Y. Shinkai, C. Yamamoto, Y. Fujiwara, Y. Kumagai and T. Kaji. 2017. Biglycan Intensifies ALK5–Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells. J Cell Biochem, DOI: 10.1002/jcb.25721
He, D., Y. Ariska, K. Masuda, M. Yamamoto and N. Takeda. 2017. A Photoresponsive Soft Interface Reversibly Controls Wettability and Cell Adhesion by Conformational Changes in a Spiropyran-conjugated Amphiphilic Block Copolymer. Acta Biomateriala, dx.doi.org/10.1016/j.actbio.2017.01.049.
Bovine Coronary Artery Endothelial Cells: BCAEC
Beltrán-Partida, E., B. Valdéz-Salas, A. Moreno-Ulloa, A. Escamilla, M. Curiel, R. Rosales-Ibáñez, F. Villarreal, D. Bastidas and J. Bastidas. 2017. Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes. J Nanobiotech, 15:10.
Hara, T., T. Kojima, H. Matsuzaki, T. Nakamura, E., Yoshida, Y. Fujiwara, C. Yamomoto, S. Saito and T. Kaji. 2017. Induction of Syndecan-4 by Organic–Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells. Int J Mol Sci, 18:352.
Canine Aortic Endothelial Cells: CnAOEC
Witter, L, E. Gruber, F. Lean and T. Stokol. 2017. Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines. Am J Vet Res, 78:69-79.
Murahari, S., A. Jalkanen, S. ulp, C. Chen, J. Modiano, C. London and W. Kesseberth. 2017. Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis. BMC Cancer, 17:67.
Liao, Y., Y. Deng, J. Liu, Z. Ye, Z. You, S. Yao and S. He. 2017. MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression. Gynecologic Oncology, 143:655-663.
Muranen, T., M.Iwanicki, N. Curry, J. Hwang, C. DuBois,J. Coloff, D. Hitchcock, C. Clish, J. Brugge and N. Kalaany. 2017.Starved epithelial cells uptake extracellular matrix for survival. Nature Commumicatins, 8: doi:10.1038.
Collett, J., P. Mehrotra, A. Crone, W. Shelley, M. Yoder and. Basile. 2017. Endothelial colony forming cells ameliorate endothelial dysfunction via secreted factors following ischemia-reperfusion injury. Am J Physiol- Renal Physiol, doi:10.1152/ajprenal.00643.2016.
Human Bronchial Epithelial Cells: HBEpC
Chakraborty, S., V. Castranova, M. Perez and G. Piedimonte. 2017. Nanoparticles-induced apoptosis of human airway epithelium is mediated by proNGF/p75NTR signaling. J Toxicol & Env Hlth, Pt A, 80:53-68.
Human Cardiac Fibroblasts: HCF
Ross, G., T. Bajwa, S. Edwards, L. Emelyanova, F. Rivi, E. Holmuhamedov, P. Werner, F. Downey, A. Tajik and A. Jahangir. 2017. Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart. Biology Open Advance article
Dou, P., R. Hu, W. Zhu, Q. Tang, D Li, H. Li and W. Wang. 2017. Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes. Die Pharmazie, 72:113-117.
Varnum, B., C. Vezina, A. Witte, X. Qian, F. Martin, H. Huang and G. Elliott. 2017. Therapeutic human anti-IL-1R1 monoclonal antibody. Patent US 9534053 B2.
Human Chondrocytes-Osteoarthritis: HC-OA
Dou, P., R. Hu, W. Zhu, Q. Tang, D Li, H. Li and W. Wang. 2017. Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes. Die Pharmazie, 72:113-117.
Dou, P., R. Hu, W. Zhu, Q. Tang, D Li, H. Li and W. Wang. 2017.Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes. Die Pharmazie, 72:113-117.
Human Coronary Artery Endothelial Cells: HCAEC
Clayton, Z., G. Yuen, S. Sadeghipour, J. Jywood, J. Wong, N. Huang, M. Ng, J. Cooke and S. Patel. 2017. A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease. Intl J. Cardiol, dx.doi.org/10.1016/j.ijcard.2017.01.125
Dela Paz, N., B. Belchior and J. Frangos. 2017.Shear stress induces Gαq/11 activation independent of G protein-coupled receptor activation in endothelial cells. Am J Physiol – Cell Physiol, DOI: 10.1152/ajpcell.00148.2016
Cruz, L., N. Streck, K. Ferguson, T. Desai, D. Desai, S. Amin and N. Buchkovich. 2017. Potent Inhibition of HCMV by Modulating the Cellular SNARE Syntaxin 5. J Virol, doi:10.1128/JVI.01637-16.
Gardner, A., P. Montgomery, Y. Zhao, F. Silva-Palacios, Z. Ungvari, A. Csiszar and W. Sonntag. 2017. Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease. J Vasc Surg, dx.doi.org/10.1016/j.jvs.2016.12.108.
Fercana, G., S. Yerneni, M. Billaud, J. Hill, P. VanRyzin, T. Richards, B. Sicari, S. Johnson, S. Badylak, P,. Campbell, T. GLEASON and J. Phillippi. 2017. Perivascular extracellular matrix hydrogels mimic native matrix microarchitecture and promote angiogenesis via basic fibroblast growth factor. Biomaterials, 123:142-154.
Gardner, A., P. Montgomery, Y. Zhao, F. Silva-Palacios, Z. Ungvari, A. Csiszar and W. Sonntag. 2017. Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease. J Vasc Surg, dx.doi.org/10.1016/j.jvs.2016.12.108.
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
Xue, Y, T. Yatsenko, A. Patel, D. Stolz, J. Philippi, V. Sant and S. Sant. 2017. PEGylated poly(ester amide) elastomer scaffolds for soft tissue engineering. Polymers for Adv Tech, DOI: 10.1002/pat.4002.
Human Fibroblast-Like Synoviocytes: HFLS
Fan, W., W. Wang, J. Wu, L. Ma and J. Guo. 2017. Identification of CD4+ T-cell-derived CD161+ CD39+ and CD39+CD73+ microparticles as new biomarkers for rheumatoid arthritis. Future Medicine, 11:107-116.
Yuki, A., T. Mitsuyoshi, R. Kunimatsu, N. Hirose, S. Su, T. Awada, K. Tanne and K. Tanimoto. 2017. Hyaluronan enhances proteoglycan4 expression in synovial cells. Mes Res Arch, 51:1-56.
Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis: HFLS-RA
Jones, D., A. Jenny, J. Swantek, J. Burke, D. Lauffenburger and P. Sorger. 2017. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nature Chem Biol, 13:38-45.
Yao, Y., C. Jiang, N. Sun, W. Li, Y. iu, H. Han, Z. Miao, X. Zhao, J. Zhao and J. Li. 2017. Tamaractam, a New Bioactive Lactam from Tamarix ramosissima, Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Molecules 22:96.
Human Growth Hormone: HGH ELISA Kit
Guerra, A., W. Rose, P. Hematti and W. Kao. 2017. Minocycline enhances the mesenchymal stromal/stem cell pro-healing phenotype in triple antimicrobial-loaded hydrogels. Acta Biomaterialia, dx.doi.org/10.1016/j.actbio.2017.01.021.
Human Hair Follicle Dermal Papilla Cells: HFDPC
Wang, Z., Y. Feng, L. Ma, X. Li, W. Ding and X. Chen. 2017. Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss. Biomed & Pharmacother, 89:438-446.
Human Hair Follicle Dermal Papilla Cell Media
Wang, Z., Y. Feng, L. Ma, X. Li, W. Ding and X. Chen. 2017. Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss. Biomed & Pharmacother, 89:438-446.
Human Mesenchymal Stem Cells: HMSC
Tsao, Y., Y. Shih, Y. Liu, Y. Liu and O. Lee. 2017. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Stem Cell Res & Ther, 8:39
Human MesoEndo Endothelial Cell Media
Gardner, A., P. Montgomery, Y. Zhao, F. Silva-Palacios, Z. Ungvari, A. Csiszar and W. Sonntag. 2017. Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease. J Vasc Surg, dx.doi.org/10.1016/j.jvs.2016.12.108.
Tarade, D., D. Ma, C. Pignanelli, F. Mansour, D. Simard, S. van den Berg, J. Gauld, J. MNulty and S. Pandey. 2017. Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest. PLoS ONE 12(3): e0171806.
Varley, M., A. Markaki and R. Brooks. 2017. Effect of Rotation on Scaffold Motion and Cell Growth in Rotating Bioreactors.Tiss Eng, DOI: 10.1089/ten.TEA.2016.0357.
Human Osteoblast Differentiation Medium
Hatakeyama, H. and Y. Goto. 2017. Respiratory Chain Complex Disorganization Impairs Mitochondrial and Cellular Integrity: Phenotypic Variation in Cytochrome c Oxidase Deficiency. Am J Pathol, 187:110-121.
Stevenson, G., S. Rehman, E. Draper, E. Hernández-Nava, J. Hunt and J. Haycock. 2017. Combining 3D Human In Vitro methods for a 3Rs Evaluation of Novel Titanium Surfaces in Orthopaedic Applications. Biotech & Bioeng, DOI 10.1002/bit.25919.
Tarade, D., D. Ma, C. Pignanelli, F. Mansour, D. Simard, S. van den Berg, J. Gauld, J. MNulty and S. Pandey. 2017. Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest. PLoS ONE 12(3): e0171806.
Tarade, D., D. Ma, C. Pignanelli, F. Mansour, D. Simard, S. van den Berg, J. Gauld, J. MNulty and S. Pandey. 2017. Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest. PLoS ONE 12(3): e0171806.
Human Peripheral Blood Monnuclear Cells: HPBMC
Ota, K. and S. Tanaka. 2017. ANIMAL CELL CULTURE MEDIUM AND CULTURE CONTAINER. Patent Application 20170022477 A1.
Human Renal Proximal Tubular Epithelial Cells: HRPTEpC
Bidwell, G., F. Mahdi, Q. Shao, O. Logue, J. Waller, C. Reese and A. Chade. 2017. A kidney-selective biopolymer for targeted drug delivery. Am J Physiol Renal Physiol, 312: F54-F64.
Bidwell, G., F. Mahdi, Q. Shao, O. Logue, J. Waller, C. Reese and A. Chade. 2017. A kidney-selective biopolymer for targeted drug delivery. Am J Physiol Renal Physiol, 312: F54-F64.
Human Smooth Muscle Cell Media
Gu, H., X. Chen, Q. Yu, X. Liu, W. Zhan, H. Che and J. Brash. 2017. A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion. J Mater Chem B, 5:604-611.
Jones, D., A. Jenny, J. Swantek, J. Burke, D. Lauffenburger and P. Sorger. 2017. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nature Chem Biol, 13:38-45.
Yao, Y., C. Jiang, N. Sun, W. Li, Y. iu, H. Han, Z. Miao, X. Zhao, J. Zhao and J. Li. 2017. Tamaractam, a New Bioactive Lactam from Tamarix ramosissima, Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Molecules 22:96.
Porcine Aortic Endothelial Cells: PAO
Bidarimath, M., K. Khalaj, R. Kridli, F. Kan, M. Koti, and C. Tayade. 2017. Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk. Scientific Reports, doi:10.1038/srep40476.
Human Tracheal Epithelial Cells: HTEpC
Chakraborty, S., V. Castranova, M. Perez and G. Piedimonte. 2017. Nanoparticles-induced apoptosis of human airway epithelium is mediated by proNGF/p75NTR signaling. J Toxicol & Env Hlth, Pt A, 80:53-68.
Human Umbilical Vein Endothelial Cells: HUVEC
Sagara, A., T. Karawawa, K. Igarashi, M. Otsuka, R. Sugiura, A. Kodama, M. Yamashita, M. Narita and Y. Kato. 2017. Controlled Secretion of the Anticancer Protein MDA-7 from Engineered Mesenchymal Stem Cells. Biol Pharm Bull 40:113-117.
Shamini, N., A. Michelsen, P. Nilsson, K. Ekholt, L. Gullestad, K. Broch, C. Dahl, P. Aukrust, T. Ueand, T. Mollnes, A. Yndestad & M. Louwe. The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports, 7, 42532.
Szymiczek, A., S. Pastorino, D. Larson, M. Tanji, L. Pellegrini, J. Xue, S. Li, C. Giorgi, P. Pinton, Y. Takinishi, H. Pass, H. Furuya, G. Gaudino, A. Napolitan, M. Carbone and H. Yang. 2017. FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. J Translational Med, 15:58.
Zhao, G., X. Cheng, L. Piao, L. Hu, Y. Lei, G. Yang, A. Inoue, S. Ogasawara, H. Wu, N. Hao, K. Okumara and M. Kuzuya. 2017. The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice. Aging and Disease, 8(3).
Rat Aortic Endothelial Cells: RAOEC
Bosc, L., J. Osmond, W. Giermakowska, C. Pace, J. Riggs, Ol Jackson-Weaver and N. Kanagy. 2017. NFAT Regulation of Cystathionine Gamma Lyase Expression in Endothelial Cells is Impaired in 2 Rats Exposed to Intermittent Hypoxia. Am J Physiol Heart Circ Physiol, doi:10.1152/ajpheart.00952.2015.
Masuda, Y., S. Yokose and H. Sakagami. 2017. Gene Expression Analysis of Cultured Rat-Endothelial Cells after Nd:YAG Laser Irradiation by Affymetrix GeneChip Array. In Vivo, 31:51-54.
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
Rat Aortic Smooth Muscle Cells: RAOSMC
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
Porcine Endothelial Cell Media
Bidarimath, M., K. Khalaj, R. Kridli, F. Kan, M. Koti, and C. Tayade. 2017. Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk. Scientific Reports, doi:10.1038/srep40476.
Fuji, M., K. Yamanouchi, Y. Saka, Z. Baimakhanov, I. Yamaguchi, A. Soyam, M. Hidka, M. Takatsuki, T. Kurokiand S. Eguchi. 2017. In vivo construction of liver tissue by implantation of a hepatic non-parenchymal/adipose-derived stem cell sheet. J. Tiss Eng & Regen Med, DOI:10.1002/term.2424.
Masuda, Y., S. Yokose and H. Sakagami. 2017. Gene Expression Analysis of Cultured Rat-Endothelial Cells after Nd:YAG Laser Irradiation by Affymetrix GeneChip Array. In Vivo, 31:51-54.
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
Kim, H., K. Jang, J. Shin, D. Kang, S. Kim, I. Kob, Y. Hong, S. Jang, M. Kim, B. Kim, H. Jeong, N. Jeong, P. Kim and K. Suh. 2017. Artificial Slanted Nanocilia Array as a Mechanotransducer for Controlling Cell Polarity. ACS Nano, DOI: 10.1021/acsnano.6b07134.
Kim, H., K. Jang, J. Shin, D. Kang, S. Kim, I. Kob, Y. Hong, S. Jang, M. Kim, B. Kim, H. Jeong, N. Jeong, P. Kim and K. Suh. 2017. Artificial Slanted Nanocilia Array as a Mechanotransducer for Controlling Cell Polarity. ACS Nano, DOI: 10.1021/acsnano.6b07134.
Bidarimath, M., K. Khalaj, R. Kridli, F. Kan, M. Koti, and C. Tayade. 2017. Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk. Scientific Reports, doi:10.1038/srep40476.
Mitsuyoshi, H., K. Yasui, T. Hara, H. Taketani, H. Ishiba, A. Okajima, Y. Seko, A. Umemura, T. Nishkawa, K. Yamaguchi m. Moriguchi, M. Minami and Y. itoh. 2017. Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of nonalcoholic fatty liver disease. Wiley, doi: 10.1111/hepr.12883.
Table 1.
Non-human expression systems used in the production of biotherapeutics approved in the United States and Europea,b.Expression system Biotherapeutic product FDA approval EMA approval Plant cells Enzymes Taliglucerase alfa Approved NA Insect cells Vaccines Cervical cancer vaccine Approved Approved Bacteria Monoclonal antibodies Certolizumab pegol Approved Approved Cytokines tbo-filgrastim Approved NA Romiplostim Approved Approved Enzymes Asparaginase Erwinia chrysanthemi Approved NA Glucarpidase Approved NA Pegloticase Approved Approved Collagenase Clostridium histolyticum Approved NA Peptides Approved NA Metreleptin Therapeutic toxins Approved NA Incobotulinumtoxin A Vaccines Meningitis vaccine Approved Approved Pneumococcal vaccine Approved Approved Yeast Enzymes Ocriplasmin Approved Approved Peptides Albiglutide Approved Approved Liraglutide Approved Approved Clotting factors Catridecacog Approved Approved Mammalian (non-human) cell lines CHO Monoclonal antibodies Adalimumab Approved Approved Alemtuzumab Approved NA Bevacizumab Approved Approved Brentuximab vedotin Approved Approved Denosumab Approved Approved Golimumab Approved Approved Ibritumomab tiuxetan Approved Approved Ipilimumab Approved Approved Obinutuzumab Approved Approved Omalizumab Approved Approved Panitumumab Approved Approved Pertuzumab Approved Approved Rituximab Approved Approved Siltuximab Approved Approved Tocilizumab Approved Approved Trastuzumab Approved Approved Vedolizumab Approved Approved Ado-trastuzumabemtansine Approved Approved Ustekinumab Approved Approved Cytokines Darbepoetin alfa Approved Approved Interferon beta-1a Approved Approved Epoetin alfa Approved Approved Epoetin beta NA NA Epoetin theta NA Approved Enzymes Agalsidase beta Approved Approved Alglucosidase alfa Approved Approved Alteplase Approved Approved Elosulfase alfa Approved NA GalNAc 4-sulfatase Approved NA Human DNase Approved Approved Hyaluronidase Approved NA Imiglucerase Approved NA Laronidase Approved NA Tenecteplase Approved Approved Fc-fusion proteins Abatacept Approved Approved Aflibercept Approved Approved Alefacept Approved Approved Belatacept Approved Approved Etanercept Approved NA Rilonacept Approved Approved Ziv-aflibercept Approved Approved Hormones Choriogonadotropin alfa Approved NA Follitropin alfa Approved Approved Follitropin beta Approved Approved Luteinizing hormone Approved Approved Osteogenic protein-1 Approved Approved Thyrotropin alfa Approved Approved Clotting factors Factor VIII Approved Approved Factor IX Approved Approved NS0 Monoclonal antibodies Belimumab Approved Approved Natalizumab Approved Approved Ofatumumab Approved Approved Palivizumab Approved Approved Ramucirumab Approved NA Sp2/0 Monoclonal antibodies Abciximab Approved NA Basiliximab Approved Approved Canakinumab Approved Approved Cetuximab Approved Approved Infliximab Approved Approved BHK Clotting factors Factor VIIa Approved Approved Factor VIII Approved Approved Murine C127 Hormones Somatropin Approved Approved FDA, US Food and Drug Administration; EMA, European Medicines Agency; NA, not approved; CHO, Chinese hamster ovary; BHK, baby hamster kidney.
aData obtained from publically available resources (October 2014); all approved products may not be included.
bReferences: (ABSEAMED®, 2012; ACTEMRA®, 2013; ACTILYSE®, 2014; ACTIVASE®, 2012; ADCETRIS®, 2013; ADVATE®, 2014; ALDURAZYME®, 2008; ARANESP®, 2006; ARCALYST™, 2008; ARZERRA®, 2014; AVASTIN®, 2010; AVONEX®, 2007; BENEFIX®, 2012; BENLYSTA®, 2011; CAMPATH®, 2014; CATHFLO® ACTIVASE®, 2010; CEREZYME®, 2010; CERVARIX®, 2012; CIMZIA®, 2013; CIMZIA®, 2014; CYRAMZA®, 2014; ELELYSO™, 2014; ENBREL®, 2010; ENTYVIO®, 2014a,b; EPERZAN™, 2014; Epoetin alfa HEXAL®, 2012; EPORATIO®, 2009; ERBITUX®, 2009; ERWINAZE®, 2011; EYLEA®, 2012; EYLEA®, 2013; FABRAZYME®, 2006; FERTAVID®, 2009; FOLLISTIM®, 2011; GAZYVA™, 2014; GAZYVARO®, 2014; Ghaderi et al., 2012; GONAL-F®, 2010; GRANIX™, 2014; HELIXATE® NexGen, 2010; HERCEPTIN®, 2010; HUMIRA®, 2008; HYLENEX®, 2012; ILARIS®, 2014; JETREA®, 2012; JETREA®, 2013; KADCYLA®, 2013, 2014; KOGENATE® Bayer, 2010; KRYSTEXXA®, 2013; LUMIZYME®, 2010; LUVERIS®, 2005; MABTHERA®, 2008; MENVEO®, 2010; METALYSE®, 2006; MYALEPT™, 2014; MYOZYME®, 2011; NAGLAZYME®, 2005; NOVOSEVEN®, 2006; NOVOTHIRTEEN®, 2012; NPLATE®, 2009; NULOJIX®, 2011; OBIZUR™, 2014; Office of Device Evaluation and Center for Devices and Radiological Health, 2001; OPGENRA®, 2014; ORENCIA®, 2012; OVIDREL®, 2014; OVITRELLE®, 2006; PERJETA®, 2013a,b; PREVNAR®, 2009; PROCRIT®, 2000; PROLIA®, 2010; PULMOZYME®, 2010; RAXIBACUMAB™, 2014; REBIF®, 2008; REFACTO AF®, 2014; REMICADE®, 2009; REOPRO®, 2013; RITUXAN®, 2014; ROACTEMRA®, 2013; SAIZEN®, 1987; SEROSTIM®, 1987; SIMPONI®, 2009; SIMULECT®, 2008; Somatropin Biopartners, 2013; STELARA®, 2013; Swiech et al., 2012; SYLVANT®, 2015; SYLVANT™, 2014; SYNAGIS®, 2009; TANZEUM™, 2014; tbo-filgrastim, 2012; THYROGEN®, 2010; TNKASE®, 2011; TRETTEN®, 2014; TYSABRI®, 2011; US Food and Drug Administration, 2010, 2011, 2012, 2013, 2014; Vectibix®, 2014; Victoza®, 2009; VIMIZIM®, 2014a,b; VORAXAZE®, 2012; XEOMIN®, 2014; XIAFLEX®, 2014; XOLAIR®, 2010; XYNTHA®, 2011; YERVOY®, 2011; ZALTRAP®, 2013a,b; ZEVALIN®, 2009).
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Table 2.
Human cells lines and their therapeutic protein productsa,b.Cell line Product Indication FDA approval status EMA approval status HEK293 Drotrecogin alfa Severe septicemia/septic shock Approved 2001; withdrawn 2011 Approved 2002; withdrawn 2011 rFVIIIFc Hemophilia A Approved 2014 Submitted 2014 rFIXFc Hemophilia B Approved 2014 NA Dulaglutide Type 2 diabetes Approved 2014 Submitted 2014 Human-cl rhFVIII Hemophilia A Submitted to the FDA Approved 2014 HT-1080 Agalsidase alfa Fabry disease NA Approved 2001 Epoetin delta Anemia secondary to chronic renal failure NA Approved 2002; withdrawn 2009 (Europe) Idursulfase Hunter syndrome Approved 2006 Approved 2007 Velaglucerase alfa Type 1 Gaucher disease Approved 2010 Approved 2010 PER.C6 CL184 Rabies virus infection Submitted to the FDA NA MOR103 Rheumatoid arthritis, multiple sclerosis Phase 1 clinical development Phase 1 clinical development FDA, US Food and Drug Administration; EMA, European Medicines Agency; HEK, human embryonic kidney; NA, not approved; rFVIIIFc, recombinant factor VIII Fc fusion protein; rFIXFc, recombinant factor IX Fc fusion protein; rhFVIII, recombinant human factor VIII.
aData obtained from publically available resources (October 2014); all approved products may not be included.
bReferences: (ALPROLIX®, 2014; Bakker et al., 2005; Behrens et al., 2014; Casademunt et al., 2012; DYNEPO®, 2007; ELAPRASE®, 2012, 2013; ELOCTATE®, 2014; European Medicines Agency and Committee for Medicinal Products for Human Use, 2014; Glaesner et al., 2010; Octapharma, 2014; REPLAGAL®, 2006; TRULICITY™, 2014; VPRIV®, 2010a,b; XIGRIS®, 2008).
Table 3.
Comparison of human cell lines with other expression systems in the production of therapeutic proteins. -
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